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Kapoor et al.



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       should be performed at months 3, 6, 12, 18, 24 and annu-  pathological factors predicting bladder recurrence after surgical resection. Pathol Int 2009;59:642-9.
       ally thereafter (Grade C). Cystoscopy and ureteroscopy may   http://dx.doi.org/10.1111/j.1440-1827.2009.02420.x
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       recurrence-free survival (Grade D).                      in Japan. Eur Urol 2009;55:1397-409. http://dx.doi.org/10.1016/j.eururo.2009.03.003
                                                             11. Kikuchi E, Horiguchi Y, Nakashima J, et al. Lymphovascular invasion independently predicts increased
       Surveillance for any grade pT>2 or pN+ patients          disease specific survival in patients with transitional cell carcinoma of the upper urinary tract.  J Urol
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                                                             12. Kim DS, Lee YH, Cho KS, et al. Lymphovascular invasion and pT stage are prognostic factors in patients
       History, physical examination, blood work, urine cytology,   treated with radical nephroureterectomy for localized upper urinary tract transitional cell carcinoma. Urology
       and cystoscopy should be performed at months 3, 6, 12, 18,   2009;75:328-32. http://dx.doi.org/10.1016/j.urology.2009.07.1350
       24 and annually thereafter (Grade C). CXR and CTU should   13. Koda S, Mita K, Shigeta M, et al. Risk factors for intravesical recurrence following urothelial carcinoma
       be performed at months 3, 6, 12, 18, 24, 30, 36 and annually   of the upper urinary tract: no relationship to the mode of surgery. Jpn J Clin Oncol 2007;37:296-301.
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       thereafter (Grade C). Following nephron-sparing procedures,   14. Lee SE, Hong SK, Han BK, et al. Prognostic significance of tumor necrosis in primary transitional cell
       ipsilateral ureteroscopy with selective cytology or biopsy   carcinoma of the upper urinary tract. Jpn J Clin Oncol 2007;37:49-55. http://dx.doi.org/10.1093/
       should be performed at months 3, 6, 12, 18, 24 and annu-  jjco/hyl123
       ally thereafter (Grade C). Cystoscopy and ureteroscopy may   15. Li CC, Chang TH, Wu WJ, et al. Significant predictive factors for prognosis of primary upper urinary tract
       be omitted from the surveillance protocol after 10 years of   cancer after radical nephroureterectomy in Taiwanese patients. Eur Urol 2008;54:1127-37. http://
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       recurrence-free survival (Grade D).                   16. Li WM, Shen JT, Li CC, et al. Oncologic outcomes following three different approaches to the distal ureter
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       Competing interests: Dr. Kapoor is a member of the Speakers bureau for, and has received grants   2010;57:963-9. http://dx.doi.org/10.1016/j.eururo.2009.12.032
       and honoraria from, Pfizer Oncology, GSK Oncology, Novartis Oncology and Amgen. He has also   17. Lin, WC, Hu FC, Chung SD, et al. The role of lymphovascular invasion in predicting the prognosis of
       participated in clinical trials within the past 2 years with NCIC, Pfizer, GSK, Novartis and Amgen.   clinically localized upper tract urothelial carcinoma (pT1-3cN0M0). J Urol 2008;180:879-85. http://
       Dr. Allard does not have an affiliation with a pharmaceutical, medical device or communications   dx.doi.org/10.1016/j.juro.2008.05.022
       organization. Dr. Black is a member of the ad hoc Advisory Boards for Amgen, Janssen, Ferring   18. Manabe D, Saika T, Ebara S, et al. Comparative study of oncologic outcomes of laparoscopic nephrour-
       and Astellas. He has received an industry-partnered grant (2012) from GenoneDx. Dr. Kassouf   eterectomy and standard nephroureterectomy for upper urinary tract transitional cell carcinoma. Urology
                                                                2007;69:457-61. http://dx.doi.org/10.1016/j.urology.2006.11.005
       is an Advisory Board member and a speaker for Amgen and Astellas. He has also received grants   19. Margulis V, Shariat SF, Matin SF, et al. Outcomes of radical nephroureterectomy: A series from the Upper
       and honoraria from these companies. He is currently participating in unpaid clinical trials within the   Tract Urothelial Carcinoma Collaboration. Cancer 2009;115:1224-33. http://dx.doi.org/10.1002/
       past 2 years. Dr. Morash does not have an affiliation with a pharmaceutical, medical device or   cncr.24135
       communications organization. Dr. Rendon is a member of the Advisory Board and the Speakers   20. Muntener M, Schaeffer EM, Romero FR, et al. Incidence of local recurrence and port site metastasis
       bureau for Amgen, Astellas, Ferring and Janssen.         after laparoscopic radical nephroureterectomy. Urology 2007;70:864-8. http://dx.doi.org/10.1016/j.
                                                                urology.2007.07.027
                                                             21. Roscigno M, Cozzarini C, Bertini R, et al. Prognostic value of lymph node dissection in patients with
                                                                muscle-invasive transitional cell carcinoma of the upper urinary tract. Eur Urol 2008;53:794-802. http://
       This paper has been peer-reviewed.                       dx.doi.org/10.1016/j.eururo.2008.01.008
                                                             22. Saito K, Kawakami S, Fujii Y, et al. Lymphovascular invasion is independently associated with poor
                                                                prognosis in patients with localized upper urinary tract urothelial carcinoma treated surgically. J Urol
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